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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Comic skit “I Want To Be In Spring Festival Gala” (Various artistes)
n. 授权(书), 认可

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Mr Ravenscroft believes he would have had a narrower perspective if he had become a management consultant. Teaching also helped him develop a willingness to take risks — the hard way. “If you stand in front of 30 teenagers who won’t hold back when you’re doing something wrong it makes you willing to try things.”
他说:“小说忠于邦德的人物形象,邦德还是粉丝喜欢的、那个最初的硬汉邦德。”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Chinese mainland is home to two of the top three universities in Asia, according to research published last Thursday by the Times Higher Education (THE).

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

“…was checking his cell phone and chewing gum during the meeting.”

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

That possibility was backed up by a list of top-tier cities the statistics bureau began tracking recently
7. Hearing Aid
['b?d?it]
5. Gross warns: 'Ponzi Scheme! Tipping Point! Credit Supernova!'

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

上榜的密码中有几大主题,包括人名和兴趣爱好。
No. Football punditry is a mug’s game. Better to have the benefit of hindsight. There have been 20 previous World Cups. Of those, Brazil (five titles) and Germany (four), are regular contenders. Home advantage helps, with host nations winning the trophy six times. But next year’s festival of football is being held in Russia, which has the lowest-ranked team in the tournament.
One of the two artefacts which has a metal ring attach to it was discovered in the Yizheng city in western Jiangsu.
读:奔腾。奔腾的特长就是永远有一颗奔腾的芯。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Both Samsung and BlackBerry quickly put the kibosh on a report Wednesday afternoon that the two are engaged in takeover talks. But why would the world’s biggest smartphone company pay a rumored $7.5 billion for a Canadian tech company whose glory days are past? Answer: Its rich intellectual property portfolio—especially all its juicy security innovations.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

《江城警事》(Battle Creek),CBS,3月1日播出。重磅剧就是会带来这样的改变。文斯·吉利根在十几年前就为这部亦敌亦友的警探搭档剧写好了试播集剧本,当时他还不是《绝命毒师》与《风骚律师》的主创。如今它终于被CBS拍成13集连续剧了。《法律与秩序:特殊受害者》(Law & Order: SVU)和《我为喜剧狂》(30 Rock)的主演在剧中饰演一个当地警探,《拉斯维加斯》(Las Vegas)主演乔希·杜哈明(Josh Duhamel)饰演一个老练的联邦调查局探员,两人在密西根州巴托溪的塞里尔城共事,相处得很不自在。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

但我预计其他银行将效仿此举。在不涨薪的前提下,任何让优秀员工保持活力和积极性的办法都值得考虑。
此外,华为在2016年最后一季度第一次实现了2位数的全球市场占有率。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

budget
Télécom Business School in France and Prague’s University of Economics have the most gender-balanced faculty, with exactly 50 per cent women, while Switzerland’s University of Zurich is the least balanced, with only 9 per cent. Switzerland’s IMD has the most international faculty, with 94 per cent of them from overseas, while faculty at Politecnico di Milano School of Management are all Italian.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

With China now not only “fully integrated”, but perhaps starting to retreat from this position as it brings more of its supply chain onshore, unless Africa can succeed in following China’s path, he adds: “I think we are going back now to a situation where we don’t think there is any particular reason for trade to grow faster than GDP.”
4.You Don't Like Most of Your Coworkers

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 中国城镇家庭负债率升至5.5%
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

"Demolitions are now becoming increasingly terrible. I am willing to ask a question very seriously as a CPPCC National Committee member: Can we not pay so much attention to GDP? Can we choose to slow down the speed of economic development?" CUI YONGYUAN, member of the CPPCC National Committee and TV host
《一位德国女权主义先锋在痛苦中回顾过去》(A Pioneering German Feminist Looks Back in Anguish)
Have a love filled New Year!
As for his own education: He's weighing whether to enroll in university in England or maybe the U.S. to be closer to Silicon Valley. Or perhaps he'll skip college entirely and just focus on his work. 'I absolutely want to start another company,' he says. 'Serial entrepreneurs get addicted to creation. I want to be passionate. I feel really bad when I'm not doing something new.'

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

“然而,考虑到政策紧缩的延迟影响,以及房地产市场降温将在未来数个季度压制中国对大宗商品的需求,我们怀疑出口的增长势头是否还能维持下去。”

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

A network of walking and biking trails leads to other lakeside neighborhoods and to downtown, which is about 15 minutes by bicycle and 10 by car. The Walker Art Center and other museums are nearby. Hockey and skating are popular on the lakes in winter; canoeing, swimming and fishing in the summer.
The system sold around 1.1 million tickets during the 2012 Spring Festival travel rush. Last year it sold 11 million over the same period.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

上周一晚间,在MSNBC的一档节目中,主持人雷切尔·玛多询问前国务卿希拉里,她是否会做出和加拿大新总理贾斯汀·特鲁多今年早些时候类似的承诺?

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

[s?:'vei]

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 上市房企“白银时代”谋转型
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

China's Internet celebrities are estimated to create a whopping 58 billion yuan ($8.7 billion) market in 2016, far surpassing the 44 billion yuan in box office sales generated last year, according to an industry report.
美国有540位富豪入选,是世界上最多的国家。中国和德国则分别有251人和120人入选,分列二、三位。
It shifts your kid's weight to your shoulders and core instead of your back.
安娜还补充道,在巴西筹办世界杯期间,巴西人民却在遭罪。由于大型建设项目造成交通拥挤,耽误了居住在城市郊区穷人的上下班时间,她认为只有富人才会在世界杯倍感享受。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

与此同时,布拉德福德大学管理学院(Bradford University School of Management)和爱丁堡大学商学院(University of Edinburgh Business School)的排名均上升16位,分别排在第42名和第55名。剑桥大学(University of Cambridge)佳奇管理学院(Judge Business School)的排名上升15位,排在第14名。
7.你们公司的人事在一个求职网站上发现了你的简历。
愿新年带给你和你所爱的人许多美好的事物和无尽的祝福!
我们不会越俎代庖,不会超越区域去做不应是中国做的事情。
根据《每日经济新闻》报道,1980版的猴年生肖纪念邮票价格由于种种原因创下了历史新高。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 罗莱家纺副总裁钱卫离职
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

在接下来几年里,大型住宅楼盘必须遵守第87号本地法(Local Law 87)——该法要求楼盘审核能源使用量,并保持系统以最高效率运行。住宅楼是纽约市最大的温室气体排放源,其排放量占总量的37%。“能源是一大热门话题。楼盘怎样提高能源效率?”管理着超过500处房产的FirstService Residential New York的总裁丹·沃泽尔(Dan Wurtzel)说,“如果运营预算的三分之一来自能源耗费,而现在你可以降低这块成本,那么上涨维护费的压力就减轻了。”
时间:2011-11-03 编辑:Lily

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

In my life, I have dreamt of seeing the great herds of wild animals, jungles and rainforests full of birds and butterfilies, but now I wonder if they will even exist for my children to see. 我一生的梦想就是能看到成群的野生动物,茂盛的丛林和大片的雨林中到处是鸟类和蝴蝶在飞舞。但是现在我想知道我们这些小孩是否还能再看到它们?

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

韩国全州——在全州的韩屋村,仍保留着几百座传统的韩式房屋。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

['hedwei]
习及一些领导人员已经明确指出,中国将会进行可持续发展、内需为依托的经济转型,为此中国可以忍受稍微慢一些的增长速度。于是一些预言家马上就下出结论,认为中国经济会因而立即大幅减速。特别是中国曾经有过这样的先例。在1978到1993年中国领导人进行改革开放,然而在政策施行的最初阶段中国经济曾经遭遇不稳定。
The Irish. They sing, dance, drink and sing some more. The lads were singing lullabies to a little baby in Bordeaux to try and get it to go to sleep.
I'm pleased to see manufacturing jobs returning to the U.S., but I don't expect the manufacturing industry to have the galvanic effect on the economy that many hope for. Why? Because automation will sharply erode the number of jobs any factory requires. The disappearance of blue-collar and entry-level jobs is already a problem, and that problem will grow.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

公关行业胜在连基本的发邮件、说话和开会都能玩出无穷的花样。入围作品有:“我想跳上你的雷达”(别,你要跳上来雷达就完了)还有“我们找时间联系,相互更新一下情况”。我最喜欢的是这个,一位名叫迈克尔的这样写道:“希望你别介意这次广推(outreach)。”哎吗,我很介意。主动凑上去(reach out)已经够让人腻歪的了,就算你把它当名词使,还颠倒了词序,也并没啥用好吗。迈克尔,“沟通杯”(Communications cup)归你了。
伦敦时装周将不会在今年的T台上展出任何使用动物皮草的服装或配饰,使其成为第一个无动物皮草的主要时装周。
6.You Spend Time Looking For Other Jobs
Most remittances ($117 billion) came from the United States, followed by Europe ($115 billion) and the Gulf states ($100 billion).

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

"We will set the exact date and location for our operation in consideration of weather conditions, but it will not be publicised," said Park Sang-Hak, a former defector who has led a series of balloon launches
联邦控制委员会要求修订的财政计划必须在1月底前批准,举出加西亚去年提交的部份是不现实的,并过度依赖联邦资金。加西亚拒绝提交一项修订计划,包括紧缩措施。罗塞略已经表示,他将要求延长还款期限与在2月到期的延缓偿付,目前保护波多黎各避免被愤怒的债权人诉讼。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Coco
单词fatigue 联想记忆:
At least 10 students lost their chance to attend Harvard College after posting "obscene memes" to a private Facebook chat, the main Harvard student newspaper reported.
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
‘The Good Wife’ Once Will (Josh Charles), Alicia’s illicit love interest, died at the end of Season 5, this sexy CBS courtroom drama seemed as if it might droop and wither, but instead, the sixth season steamed with almost madcap energy, mixing Alicia’s newly fledged political campaign, a war of the roses between Alicia’s new firm and her old one, and the legal travails of Cary, her legal partner. Alicia isn’t quite so good anymore, and that makes “The Good Wife” all the better.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

designated
uni一个,que表形容词-独特的
根据国内领先的求职平台前程无忧近日发布的一份关于2016年应届毕业生的研究报告显示,52.11%的高校毕业生已找到工作或自主创业。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

"It's one of the strangest things that's ever happened to me," Beatty said backstage. "Thank God there were two of us up there," Dunaway responded.
4. 欧佩克的下一步行动。说到去年的油价暴跌,石油输出国组织(OPEC)起了很大作用(或者说要承担很大责任)。虽然许多评论人士都说欧佩克保持原油产量不变无关紧要,然而,仅油价在该组织11月份会议过后出现暴跌这一事实便充分证明了该组织对油价走势的影响力。目前,欧佩克——更确切地说是沙特——仍在坚持己见,毫无下调生产配额的迹象。2015年这一情况是否会得以延续,仍有待观察。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

卓越雇主排名:66
这一次,湖人队处境不错,而且不需要赶着去做什么事,给他们点时间,看看他们到底会怎样。用这样的防守质量他们很难进入季后赛,但是这并不是这个赛季的重点。
此外,维密的许多其他模特也被禁止入境,包括来自俄罗斯的朱莉亚·贝亚科娃、凯特·格里戈瑞瓦和伊丽娜·莱巴里科娃以及乌克兰的达莎·凯尔斯顿。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

calculation
意大利语piloto“划浆""的变体→飞行员,领航员
Watching Under the Skin again brought to mind another comparison: Orson Welles – the Welles who succeeded in creating a hoax martian invasion on the radio and who, in F for Fake (1975), got his partner Oja Kodar to walk around the streets in a miniskirt, secretly filming the lascivious expressions of the non-actor guys looking at her.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The "Quarterly Journal of Experimental Psychology" published a study in early 2016 entitled, "The drawing effect: Evidence for reliable and robust memory benefits in free recall." While the title seems a bit long and complex, the study actually demonstrated a very simple idea. Drawing words in picture form helps people make better and stronger memories. The authors of the study created simple tasks where a participant would first draw a simple word, like a common piece of fruit. Later, the authors of the study would ask the participants to recall the words they drew. Other participants in the study were given different tasks like repeating the given word aloud a certain number of times or actually writing the word down. The researchers found that participants who drew doodles of the words they needed to recall fared much better than other participants.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

国考分为笔试和面试两部分。笔试成绩将于1月发布,面试预计在2月或3月举行。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

除了印度,其他金砖国家——巴西,俄罗斯,中国和南非——也削减了对美国政府债券的持有。
那么,当你看到17岁的尼克?达洛伊西奥(Nick D’Aloisio)意气风发地走进伦敦巴尔?布鲁(Bar Boulud)餐厅,与人坚定地握着手,描绘他未来事业蓝图的时候,你应该会惊讶得合不拢嘴了吧。他就像是个来自硅谷的首席执行长(CEO),应对媒体时从容不迫,技巧上可以打97的高分。聊天时,他眼神坚定地注视着你,从诺姆?乔姆斯基(Noam Chomsky)的理论、神经网络科学,到移民心态乃至佛教瑜伽,他一切话题都能自信地畅所欲言。但他又像是个One Direction男孩组合的成员,修长的身材配着嬉皮T恤和修身小西装,头发凌乱地搭在脑门前,一边咬着吉士汉堡,一边发表着让人瞠目结舌的见解。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Rios is no stranger to hard work. She moved to the U.S. from El Salvador when she was a child. She graduated at the top of her high school class and raised a family while putting herself through college. She was not intimidated when she started Nation Waste Inc. At just 22, months after graduating from the University of Houston, she took out loans and purchased two trucks, jumping into the male-dominated waste-removal industry. Today, her Houston-based company has 24 full-time employees. "It is pretty amazing when I look back and see, I started as a little girl entering the United States with my parents and now I am truly living the American dream," says Rios.
不要马上接受一个工作录用。你需要好好考虑一下。你要是一签文件了,就没有商量的余地了。
榜单前十名中的其它外国影片为《变形金刚5:最后的骑士》、《摔跤吧!爸爸》、《加勒比海盗5:死无对证》和《金刚:骷髅岛》。
这位无懈可击的歌手用吉他和铜管乐器合成的节拍和强节奏的音乐效果展现了更为广阔的情感和音乐世界。它会使你回想起艺术摇滚乐教母凯特·布什(你可以去听一下《Green Light》(《绿灯》)这首歌)。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Episodic memory is also known as long-term memory, and the researchers approached the study of exercise in a different manner than previous studies. Other studies examined the impact of aerobic exercise conducted over many months, but this study simply asked participants to lift weights a single time. During the test, half of the participants were asked to use a weight machine before recalling a series of images they were shown at the start of the test. The other half of the participants were also asked to recall the images but without having engaged in any strenuous activity before the recall session. In demonstrating the memory improvement for the participants who engaged in just a single session of weight lifting, the researchers were able to show that improving one's memory through exercise didn't take hours of dedication in the gym. The next time you have the opportunity to lift weights or someone tries to convince you to join the gym you might just want to take him or her up on the offer.
According to the China Auto Dealers Chamber of Commerce, which is helping to organise the dealers, Hyundai’s import-only dealer network has already halved in size since 2014.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

n. 监牢,监狱,拘留所
Honda has recalled more than 10 million vehicles in the U.S. to fix a potentially fatal defect in air bags made by Japanese supplier, Takata. The air bag inflators can rupture after a crash and injure occupants with shards of metal. Honda has confirmed three deaths and 48 injuries in connection with such incidents.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

2016年重庆市GDP增长了10.7%,达到了1.76万亿元人民币。贵州和西藏分别实现了10.5%和10%的GDP增长。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Track field;hand ball;cycling;track racin;racing cycle;mountain bike race;Bicycle Motocross;horsemanship;football;Beach Volleyball.
一个由BuzzFeed News(译者注:类似今日头条的新闻搜集网站)所做的分析揭示了本年度Facebook上流传最广的50条假新闻。他们加起来大约有2150万次的点赞、评论及分享。在这些新闻里,23条和美国政治相关,2条关于女人用她们的阴道作为谋杀用的凶器,还有1条关于一个小丑娃娃其实一直都是个真人。
沙特王储穆罕默德·本·萨勒曼表示,多数被捕人员已同意归还部分非法获得的钱财,以换取自由。
Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

普兰特?莫兰:甜食福利惹人馋
我们当中很多人都有八卦抱怨的习惯。但是如果做的太频繁的话,工作恐怕就不保了。所有的这些会带来一个同样的结果:变成了老板的眼中的麻烦。一般来讲,老板要确保自己的团队有正面的能量,团队中如果有人是消极的,会有损他的形象。消极的员工在高级管理层中被认为是“癌细胞”,这是因为“他们早晚会被割除”。如果你有怨念的话,一个好的办法就是私底下直接和老板对话。 千万不要一开始就拉拢人心寻求支持。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 布局者众 智能家居千亿市场开启
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The American share in the total drugspending is about one third. IMS experts estimate that in 2014 it will rise11.7 percent. The UShas particularly high prices, according to the report, but drug makers defendthis by citing the soaring cost of new medicine development.
5.ah, you look great in that dress. – Because it’s better than being slapped。
n. 粉底霜,基

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Treasury Secretary Jacob Lew announced the plans for the new redesign Wednesday. Lew said the Treasury Department will launch a social media campaign dubbed "The New 10" to solicit ideas on whose portrait should be chosen for the new bill, along with a series of public meetings. He will reveal his decision sometime this year.
8. 赤脚能够提高记忆力
The former pupil at Audenshaw's Poplar Street Primary is studying at Withington Girls' School and starts at Altrincham Grammar School for Girls in September. She lives with her parents, Neelanga and Shiromi, who moved to Manchester from Sri Lanka in 2001. Dad Neelanga, 44, praised Nishi's first teachers at Poplar Street Primary. He said: 'We knew very early on that she was gifted. She started reading and writing very early and was became very good at mathematics. We gave her challenging, interesting things to do. As a parent, you do not want their talents to be wasted, but there has to be a balance with their childhood. She is just a normal 10-year-old, just like any other 10-year-old really. She loves reading, cycling and walking, and we're all very proud of her.'

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

“我们现在从中国看到的情况不仅仅是巴西一国的现象,我们在整个拉美都看到了同样的情况,中国对所有市场的出口都在下降,”负责马士基航运在巴西、巴拉圭、乌拉圭和阿根廷业务的执行董事安东尼奥?多明格斯(Antonio Dominguez)表示,“已经连续几个季度出现这种情况,但随着我们进入(2016)年,这种局面变得越来越明显了。”
现在基本上只能依靠其他制度(尤其是国会、法庭和媒体)以及公民。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

确实,现在的保罗更大更强壮了,但是,现在的他脸蛋和高中的自己一样。在高中的时候,保罗甚至就有了自己标记性的胡须。
要向依法依规的市场主体发出“前行、前行、再前行”的信号;向依靠劳动创业创新者亮起“可以、可以、再可以”的绿灯;对那些违法违规不良行为,就要及时亮出黄牌,甚至出红牌罚他下场。
As the new iPhone continues to smash its own launch records, Mr Cook has unveiled products such as Apple Watch and Apple Pay that take the iPhone maker into the realms of fashion and finance, recapturing a spirit of innovation that many feared had died with Jobs. In the process, Apple’s valuation this year has grown by almost as much as Google’s entire market capitalisation.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 北京:广内地下空间变身便民仓储
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Hurricane Harvey
总的来说:世界最大经济体任然可以入常运转就如同沙漠中的绿洲就算有末世预言宣称那样的日子已经远去了。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

A major disruption still could push oil higher, but potential oversupply makes even that less likely. Emerging-market demand once kept supply so tight that any disruptions led to striking price moves, said Ole Hansen, head of commodity strategy at Saxo Bank.
品牌VS市场
In fact, academic research suggests that other economic and social transformations unfolding at the same time have led many people to anchor themselves more fully in their whiteness — even as whiteness itself has lost currency.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

时间:2010-05-31 编辑:francie

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

3. You support the teams that I support.
Initial success was achieved in supply-side structural reform.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.
这一要求出自我国交通部近日发布的关于出租车、网约车服务的两项新规其中的一项。两项新规将分别于今年10月、11月生效。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

8. Sturgill Simpson “Metamodern Sounds in Country Music” (High Top Mountain) A throwback progressive hunkered down with a whip-smart band: country music has seen this before. But on his breakthrough second album, Sturgill Simpson made it a pliable trademark, grounded at every turn by his winning, seen-it-all baritone.
但是,租金稳定政策的反对者怀疑,在共和党人把持州议会的情况下,2015年将不会是租户运动的分水岭。舍温·贝尔金(Sherwin Belkin)是一名代表业主利益的律师,他说:“业主们认为可以借此机会对租金管制政策做一些亟需的改变。”

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Tom Hanks and Meryl Streep in front of the camera, with Steven Spielberg directing a historic battle over press freedom - there's much for awards voters to admire.
赖特是英国浪漫主义画派的鼻祖之一。这幅作品从1840年起一直由德比郡的一个家族私藏。考虑到目前的行情,它的最低估价仅为10万英镑,还有一个重要因素是它的拍卖款将用于救济叙利亚难民。结果,至少有三位竞拍人把价格推高至66.5万英镑(含佣金)。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

But the change in Wall Street’s — and Silicon Valley’s — appreciation of Mr Cook is down to more than just the 70m iPhones Apple is expected to sell this quarter or the $42bn in sales generated in the previous.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

In 2016, fear and anger became dominant political emotions in the UK and the US — two of the most important, stable and enduring democracies.
对于该行业规模有多大,众说纷纭,但高盛(Goldman Sachs)的数据表明,在2012至2014年期间,该行业的贷款规模从60亿元人民币增长至830亿元。
n. 毂,木片,中心
9.《老友记》中卡罗尔和苏珊的婚礼

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 二季度中介业就业最景气
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

[kri'eitiv]

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Will Indian Prime Minister Narendra Modi try any more unorthodox economic experiments
Lecent Ross枪击案已逮捕两人
The Datafolha poll was based on interviews with 693 fans at the Mineirao stadium in Belo Horizonte and had a statistical margin of error of 4 percentage points.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.
我发现自己很难开启一段对话

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

新加坡樟宜国际机场已经连续五年在每年一度的Skytrax世界机场大奖评选中获得世界最佳机场。
Falke的最终失利令人扼腕,但eBay的表现确实无可匹敌。我以为自己对eBay的爱将矢志不渝,因为鄙人全部的穿戴和家中物件均来自这家公司,而它却向《纽约时报》(the New York Times)表示:“我们热切希望利用我们的平台,通过营造公平的竞争环境来造福数百万人。”

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Some hits have gone so far over the top they should be winded, yet instead keep on puffing gusts of hot air, including “Downton Abbey,” “Scandal” and “Revenge.” A new addition on ABC, “How to Get Away With Murder” was a fun substitute, a lurid nighttime soap opera about lawbreaking defense lawyers — “Law & Disorder.”

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Faber laughs at Bernanke's remark that the economy would be strong enough later this year so he could take his foot off the gas, that is begin 'tapering, or scaling back it's stimulative quantitative easing (QE) program later this year.' Yes, laughed.
连续4年以来,排行榜前5名的位置都被相同的五个跨洲EMBA项目所占据。Tiemba项目今年能够荣登榜首,不是因为它比竞争对手表现得异常优秀,而是得益于在大多数指标上的强劲表现。尤其是,该项目学员的平均薪资(32.4万美元)排名第二,仅次于凯洛格-香港科大(Kellogg-HKUST)EMBA项目的学员(40.8万美元)。Tiemba项目在职业晋升方面也位居第二,在工作经验方面排名第四。
The data was released to encourage the adoption of stronger passwords. Mr Slain added:"As always, we hope that with more publicity about how risky it is to use weak passwords, more people will start taking simple steps to protect themselves by using stronger passwords and using different passwords for different websites."

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Think you’ve had some bad job interviews this year? This survey is guaranteed tcheer you up (unless you happen tbe part of it). When staffing firm OfficeTeam asked 600 managers across North America tdescribe the most embarrassing interview blunders they had seen in 2014, here’s what they said.
Regardless of whether or not you think Snapchat is worth the $3 billion Facebook offered it, one thing is clear: There's an appetite out there for so-called ephemeral networks, where content literally vanishes seconds after being received. And, contrary to popular perception, this isn't just about sexting and X-rated selfies (though it definitely is about that, too). As content on the major networks becomes more corporate and commoditized, Snapchat and services like it restore some of the fun and spontaneity to social media. Just like a real-life interaction -- where ideas flow freely and you generally don't worry about everything being recorded for posterity and broadcast to the world -- SnapChat and networks like it offer a channel for genuine, unfiltered exchange. And the kids really like it. While Facebook's own CFO officially acknowledged last month that teen use of his network is declining, the number of teens on SnapChat -- at least anecdotally -- is exploding.
其中包括“qwerty”(键盘字母顺序,排名第4)、“admin”(管理员,排名第11)和“login”(登录,排名第14)。
This assumes, of course, that Apple can find a way to build a $330 iPhone with cheaper parts, a slower processor, a lower resolution screen and perhaps a plastic body, thatisn't, in the phrase Tim Cook used at a Goldman Sachs conference last week, "a crappy product."

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

上海交易所和深圳交易所总共完成了61宗IPO交易,较2015年同期分别下滑了67%。融资总额288亿元人民币,较2015年同期分别下滑了80%。
5. Gross warns: 'Ponzi Scheme! Tipping Point! Credit Supernova!'

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Fast & Furious 6 helped place two other actors high on our list: Vin Diesel and the late Paul Walker. Diesel lands in fourth place with $887 million. Fast & Furious 6 earned $789 million at the box office worldwide. The third movie in his Riddick franchise hit theaters just a few months after. It only pulled in $98 million, but that was enough to put Diesel ahead of his co-star Walker on our list.
一有机会就炫一下小卷毛。
不过幸好y一位Siddeeq先生的朋友看到了电视新闻于是联系了他。Siddeeq先生表示他依然非常希望看到这封信,虽然他和写信的未婚妻已经离婚了。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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9. The Chinese militarywill demand and receive vastly expanded investments in the form of advancedaircraft and ships.
据BT下载网站TorrentFreak数据显示,《权力的游戏》每集平均下载人数有590万。这个数字还不包括在线视频和cyberlocker的下载方式,如果算上这种方式,数据将会更高。而《权力的游戏》每一集的平均收视人数才550万。

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